Hitoshi Osaka Selected Research

Temporal Lobe Epilepsy

1/2022

CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate.

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Hitoshi Osaka Research Topics

Disease

11	Brain Diseases (Brain Disorder) 02/2024 - 01/2012
10	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2024 - 09/2004
9	Mitochondrial Diseases (Mitochondrial Disease) 01/2024 - 10/2013
8	Epilepsy (Aura) 01/2024 - 06/2007
8	Pelizaeus-Merzbacher Disease 12/2023 - 10/2002
8	Seizures (Absence Seizure) 01/2022 - 02/2010
8	Leukoencephalopathies 12/2021 - 07/2011
5	Leigh Disease (Leigh's Disease) 12/2021 - 02/2018
4	MELAS Syndrome (Syndrome, MELAS) 11/2019 - 10/2013
4	Methylenetetrahydrofolate reductase deficiency 02/2017 - 06/2011
3	Intellectual Disability (Idiocy) 01/2024 - 08/2014
3	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 10/2023 - 10/2017
3	Movement Disorders (Movement Disorder) 01/2019 - 04/2015
3	Encephalitis (Encephalitis, Rasmussen) 04/2016 - 09/2011
3	Parkinson Disease (Parkinson's Disease) 01/2007 - 04/2003
2	Menkes Kinky Hair Syndrome (Menkes Disease) 01/2024 - 04/2014
2	Inflammation (Inflammations) 01/2024 - 10/2019
2	Dystonia (Limb Dystonia) 12/2021 - 01/2017
2	Paraplegia (Spastic Paraplegia) 12/2021 - 07/2011
2	Acute Disseminated Encephalomyelitis (Postinfectious Encephalomyelitis) 10/2020 - 08/2018
2	Muscular Diseases (Myopathy) 05/2019 - 01/2013
2	Alexander Disease (Alexander's Disease) 02/2019 - 08/2018
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 05/2012
2	Congenital Disorders of Glycosylation 01/2019 - 02/2014
2	Myoclonus (Nocturnal Myoclonus) 01/2018 - 04/2015
2	Infantile Epileptic-Dyskinetic Encephalopathy 01/2018 - 01/2012
2	Gamma aminobutyric acid transaminase deficiency 05/2017 - 02/2010
2	Atrophy 01/2017 - 01/2013
2	Anti-N-Methyl-D-Aspartate Receptor Encephalitis 04/2016 - 01/2013
2	Myoclonic Epilepsies (Myoclonic Encephalopathy) 02/2015 - 07/2010
2	Schizencephaly 01/2015 - 01/2013
2	Drug Resistant Epilepsy 01/2015 - 02/2014
2	Porencephaly 01/2013 - 01/2012
2	Polyneuropathies (Polyneuropathy) 09/2012 - 06/2011
2	Human Influenza (Influenza) 01/2012 - 06/2006
1	Mitochondrial Myopathies (Mitochondrial Myopathy) 02/2024
1	Brain Ischemia (Cerebral Ischemia) 02/2024
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2023
1	Acute Liver Failure (Fulminant Hepatic Failure) 10/2023
1	Generalized Epilepsy 07/2023
1	Cardiomyopathies (Cardiomyopathy) 09/2022
1	Hypertrophy 09/2022
1	Pathologic Constriction (Stenosis) 09/2022
1	Hypoglycemia (Reactive Hypoglycemia) 09/2022
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 09/2022
1	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 01/2022
1	Temporal Lobe Epilepsy 01/2022

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2024 - 10/2002
5	Adenosine Triphosphate (ATP)IBA 01/2022 - 05/2012
5	Lactic Acid (Lactate)FDA LinkGeneric 05/2019 - 04/2013
4	Protons (Proton)IBA 01/2014 - 02/2010
3	Biomarkers (Surrogate Marker)IBA 01/2024 - 11/2019
3	CholesterolIBA 10/2023 - 10/2017
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 02/2014
3	Collagen Type IV (Type IV Collagen)IBA 01/2021 - 01/2012
3	Mitochondrial DNA (mtDNA)IBA 01/2018 - 01/2015
3	4- (2,4- difluorophenyl)- 2- (1H- indol- 3- yl)- 4- oxobutanoic acidIBA 06/2017 - 01/2015
3	Folic Acid (Vitamin M)FDA LinkGeneric 01/2014 - 06/2011
3	UbiquitinIBA 01/2007 - 04/2003
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2024 - 11/2019
2	CopperIBA 01/2024 - 04/2014
2	Apomorphine FDA Link 01/2024 - 11/2019
2	CurcuminIBA 12/2023 - 05/2012
2	Lacosamide FDA Link 07/2023 - 04/2020
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 07/2012
2	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022 - 10/2016
2	Myelin-Oligodendrocyte GlycoproteinIBA 10/2020 - 08/2018
2	Glial Fibrillary Acidic ProteinIBA 02/2019 - 08/2018
2	Anticonvulsants (Antiepileptic Drugs)IBA 05/2017 - 09/2011
2	HomocysteineIBA 02/2017 - 06/2011
2	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 02/2017 - 07/2011
2	TubulinIBA 01/2017 - 06/2014
2	gamma-Aminobutyric Acid (GABA)IBA 10/2016 - 02/2010
2	EnzymesIBA 10/2016 - 01/2012
2	AntioxidantsIBA 01/2016 - 01/2015
2	Valproic Acid (Depakote)FDA LinkGeneric 02/2015 - 01/2012
2	CreatineIBA 01/2015 - 01/2014
2	X-linked Creatine deficiencyIBA 01/2015 - 08/2014
2	CreatinineIBA 01/2015 - 01/2014
2	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 05/2014 - 02/2014
2	Intravenous Immunoglobulins (IVIG)FDA Link 01/2013 - 06/2010
2	Voltage-Gated Sodium ChannelsIBA 07/2010 - 06/2007
2	HydrolasesIBA 01/2007 - 04/2003
1	NAD (NADH)IBA 02/2024
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2024
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2024
1	Ceruloplasmin (Ferroxidase)IBA 01/2024
1	coenzyme Q10 (CoQ10)IBA 03/2023
1	Brain Natriuretic Peptide (Natrecor)FDA Link 09/2022
1	Propranolol (Inderal)FDA LinkGeneric 09/2022
1	cifenline (cibenzoline)IBA 09/2022
1	Anti-Arrhythmia AgentsIBA 09/2022
1	Biotin (Vitamin H)FDA Link 09/2022
1	Thiamine (Aneurin)FDA Link 09/2022
1	Protein Isoforms (Isoforms)IBA 01/2022

Therapy/Procedure

13	Therapeutics 02/2024 - 06/2010
2	Artificial Respiration (Mechanical Ventilation) 08/2021 - 04/2018
1	Liver Transplantation 10/2023
1	Chelation Therapy (Therapy, Chelation) 01/2022
1	Hematopoietic Stem Cell Transplantation 01/2022